Сurrent options and perspectives of systemic therapy for advanced or metastatic adrenocortical cancer
نویسندگان
چکیده
Adrenocortical cancer is an orphan tumor with poor prognosis. The combination of EDP chemotherapy regimen and mitotane the standard for first‑line therapy. But there are no effective options second consequent lines second‑line therapy gemcitabine, capecitabine mitotane, which provides objective response in 4–7 % patients. Achievement therapeutic concentration most important predictive factor efficiency GemCap + regimen, and, therefore, it recommended to continue after progression mitotane. Recently, many researches regarding targeted immunotherapy adrenocortical have been published. However, standards third subsequent treatment. This review outlines current views perspectives systemic advanced metastatic cancer.
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ژورنال
عنوان ژورنال: Zloka?estvennye opuholi
سال: 2022
ISSN: ['2587-6813', '2224-5057']
DOI: https://doi.org/10.18027/2224-5057-2021-11-3-36-44